Drug interactions
Chloral hydrate + Chlordiazepoxide-clidinium
Severity: Moderate
Chloral hydrate and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate and benzodiazepines both cause sedation and their combination can produce excessive drowsiness and respiratory depression. Risk is greater in elderly and debilitated patients.
What this interaction means in plain words
Chloral hydrate and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression via GABA-A receptor potentiation.
What to do
Use the lowest effective doses and monitor sedation level and respiratory status; avoid in patients with respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Chloral hydrate and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate and benzodiazepines both cause sedation and their combination can produce excessive drowsiness and respiratory depression. Risk is greater in elderly and debilitated patients.
How serious is the interaction between Chloral hydrate and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation level and respiratory status; avoid in patients with respiratory compromise.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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