Drug interactions
Chloral hydrate + Isoproterenol
Severity: Moderate
Chloral hydrate and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate can sensitise the heart to catecholamines, and isoproterenol is a potent beta-agonist that raises heart rate and arrhythmia risk. The combination may therefore provoke tachyarrhythmias; any stimulating offset of sedation is not clinically relevant.
What this interaction means in plain words
Chloral hydrate and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Chloral hydrate metabolites sensitise the myocardium to catecholamines, adding to isoproterenol's beta-adrenergic arrhythmogenic effect.
What to do
Monitor ECG and heart rate when isoproterenol is used after chloral hydrate. Use the lowest effective isoproterenol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Chloral hydrate with Isoproterenol?
MediHelp rates the interaction as moderate. Chloral hydrate and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate can sensitise the heart to catecholamines, and isoproterenol is a potent beta-agonist that raises heart rate and arrhythmia risk. The combination may therefore provoke tachyarrhythmias; any stimulating offset of sedation is not clinically relevant.
How serious is the interaction between Chloral hydrate and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when isoproterenol is used after chloral hydrate. Use the lowest effective isoproterenol dose.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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