Drug interactions
Chloral hydrate + Maprotiline
Severity: Moderate
Chloral hydrate and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant, so with chloral hydrate drowsiness and impaired psychomotor performance may be increased. Maprotiline also lowers seizure threshold and is hazardous in overdose, which adds importance to careful use.
What this interaction means in plain words
Chloral hydrate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from the hypnotic and the sedating antidepressant.
What to do
Monitor for oversedation and use the lowest effective doses. Counsel against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Chloral hydrate with Maprotiline?
MediHelp rates the interaction as moderate. Chloral hydrate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant, so with chloral hydrate drowsiness and impaired psychomotor performance may be increased. Maprotiline also lowers seizure threshold and is hazardous in overdose, which adds importance to careful use.
How serious is the interaction between Chloral hydrate and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and use the lowest effective doses. Counsel against alcohol and driving.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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