Drug interactions
Chloral hydrate + Orphenadrin
Severity: Moderate
Chloral hydrate and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic, and orphenadrine adds its own sedative and anticholinergic effects. The combination can cause excessive sedation, confusion and next-day impairment.
What this interaction means in plain words
Chloral hydrate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and monitor the level of sedation, especially in older adults. Avoid other sedatives and alcohol at the same time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Orphenadrin?
MediHelp rates the interaction as moderate. Chloral hydrate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic, and orphenadrine adds its own sedative and anticholinergic effects. The combination can cause excessive sedation, confusion and next-day impairment.
How serious is the interaction between Chloral hydrate and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor the level of sedation, especially in older adults. Avoid other sedatives and alcohol at the same time.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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