Drug interactions
Chloral hydrate + Quetiapine
Severity: Moderate
Chloral hydrate and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate and quetiapine are both sedating, so concurrent use may cause excessive drowsiness, confusion and falls. Quetiapine can also cause orthostatic hypotension and QT prolongation, which may add to risk.
What this interaction means in plain words
Chloral hydrate and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABAergic enhancement and quetiapine antagonism of histamine H1 and alpha-1 receptors.
What to do
Use the lowest effective doses and monitor sedation and blood pressure, particularly in older adults. Counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Chloral hydrate with Quetiapine?
MediHelp rates the interaction as moderate. Chloral hydrate and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate and quetiapine are both sedating, so concurrent use may cause excessive drowsiness, confusion and falls. Quetiapine can also cause orthostatic hypotension and QT prolongation, which may add to risk.
How serious is the interaction between Chloral hydrate and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure, particularly in older adults. Counsel on avoiding driving and alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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