Drug interactions
Chloral hydrate + Ramelteon
Severity: Minor
Chloral hydrate and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are used to promote sleep, and taking them together may lead to excess next-day drowsiness and impaired alertness. Ramelteon has weaker sedative effects than classic hypnotics, so the interaction is generally modest.
What this interaction means in plain words
Chloral hydrate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloral hydrate belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive sedation from GABAergic effects of chloral hydrate and melatonin MT1/MT2 receptor agonism by ramelteon.
What to do
Avoid routine combination of hypnotics and monitor for daytime sedation. Advise caution with driving or hazardous tasks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloral hydrate and Ramelteon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Chloral hydrate with Ramelteon?
MediHelp rates the interaction as minor. Chloral hydrate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are used to promote sleep, and taking them together may lead to excess next-day drowsiness and impaired alertness. Ramelteon has weaker sedative effects than classic hypnotics, so the interaction is generally modest.
How serious is the interaction between Chloral hydrate and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of hypnotics and monitor for daytime sedation. Advise caution with driving or hazardous tasks.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
