Drug interactions
Chloral hydrate + Sufentanil
Severity: Major
Chloral hydrate and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a potent opioid with a sedative-hypnotic markedly raises the risk of profound sedation, respiratory depression, hypotension and death. This is particularly important outside monitored anesthetic settings.
What this interaction means in plain words
Chloral hydrate and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation and mu-opioid receptor agonism.
What to do
Use only with continuous monitoring of respiration and oxygenation, with reduced doses and airway support available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Chloral hydrate with Sufentanil?
MediHelp rates the interaction as major. Chloral hydrate and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a potent opioid with a sedative-hypnotic markedly raises the risk of profound sedation, respiratory depression, hypotension and death. This is particularly important outside monitored anesthetic settings.
How serious is the interaction between Chloral hydrate and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with continuous monitoring of respiration and oxygenation, with reduced doses and airway support available.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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