Drug interactions
Chloramphenicol + Chlorpropamide
Severity: Moderate
Chloramphenicol and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit the metabolism of sulfonylureas and prolong their half-life. This may cause hypoglycemia, which can be prolonged with the long-acting chlorpropamide.
What this interaction means in plain words
Chloramphenicol and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Chlorpropamide belongs to Endocrine.
Why it happens
Inhibition of hepatic CYP2C9-mediated metabolism of chlorpropamide by chloramphenicol.
What to do
Monitor blood glucose closely during and after chloramphenicol therapy and reduce the chlorpropamide dose if hypoglycemia occurs. Teach patients the symptoms of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chloramphenicol with Chlorpropamide?
MediHelp rates the interaction as moderate. Chloramphenicol and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit the metabolism of sulfonylureas and prolong their half-life. This may cause hypoglycemia, which can be prolonged with the long-acting chlorpropamide.
How serious is the interaction between Chloramphenicol and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after chloramphenicol therapy and reduce the chlorpropamide dose if hypoglycemia occurs. Teach patients the symptoms of hypoglycemia.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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