Drug interactions
Chloramphenicol + Deflazacort
Severity: Moderate
Chloramphenicol and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort's active metabolite is formed and cleared via CYP3A4, so CYP3A4 inhibition increases systemic corticosteroid exposure. This may intensify steroid adverse effects such as infection risk, hyperglycemia and adrenal suppression.
What this interaction means in plain words
Chloramphenicol and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Deflazacort belongs to Miscellaneous.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing clearance of deflazacort's active metabolite.
What to do
Consider reducing the deflazacort dose when a CYP3A4 inhibitor is needed, as labeling suggests for moderate and strong inhibitors. Monitor for corticosteroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Deflazacort?
MediHelp rates the interaction as moderate. Chloramphenicol and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort's active metabolite is formed and cleared via CYP3A4, so CYP3A4 inhibition increases systemic corticosteroid exposure. This may intensify steroid adverse effects such as infection risk, hyperglycemia and adrenal suppression.
How serious is the interaction between Chloramphenicol and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the deflazacort dose when a CYP3A4 inhibitor is needed, as labeling suggests for moderate and strong inhibitors. Monitor for corticosteroid excess.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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