Drug interactions
Chloramphenicol + Entrectinib
Severity: Major
Chloramphenicol and Entrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is a CYP3A4 substrate, and inhibition of this enzyme raises its plasma concentrations. This may increase QT prolongation, CNS effects, heart failure and other toxicities.
What this interaction means in plain words
Chloramphenicol and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Entrectinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing the metabolic clearance of entrectinib.
What to do
Avoid the combination where possible and choose another antibiotic. If it cannot be avoided, reduce the entrectinib dose per labeling and monitor ECG and toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Entrectinib
Frequently asked questions
Can I take Chloramphenicol with Entrectinib?
MediHelp rates the interaction as major. Chloramphenicol and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib is a CYP3A4 substrate, and inhibition of this enzyme raises its plasma concentrations. This may increase QT prolongation, CNS effects, heart failure and other toxicities.
How serious is the interaction between Chloramphenicol and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antibiotic. If it cannot be avoided, reduce the entrectinib dose per labeling and monitor ECG and toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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