Drug interactions
Chloramphenicol + Ganaxolone
Severity: Minor
Chloramphenicol and Ganaxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol could theoretically increase ganaxolone exposure by inhibiting CYP3A4. Labeling indicates that changes with CYP3A4 inhibitors are not clinically significant.
What this interaction means in plain words
Chloramphenicol and Ganaxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Ganaxolone belongs to Central Nervous System.
Why it happens
Weak theoretical inhibition of CYP3A4-mediated ganaxolone metabolism.
What to do
No dose adjustment needed; be aware of possible additive sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Ganaxolone
Frequently asked questions
Can I take Chloramphenicol with Ganaxolone?
MediHelp rates the interaction as minor. Chloramphenicol and Ganaxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol could theoretically increase ganaxolone exposure by inhibiting CYP3A4. Labeling indicates that changes with CYP3A4 inhibitors are not clinically significant.
How serious is the interaction between Chloramphenicol and Ganaxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; be aware of possible additive sedation.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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