Drug interactions
Chloramphenicol + Glasdegib
Severity: Major
Chloramphenicol and Glasdegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib is metabolized mainly by CYP3A4 and carries a risk of QT prolongation. Raising its exposure may increase QT effects and other dose-related toxicities.
What this interaction means in plain words
Chloramphenicol and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Glasdegib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, decreasing glasdegib metabolism.
What to do
Choose an alternative antibiotic if possible. If unavoidable, monitor ECG and electrolytes and watch for increased adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Chloramphenicol with Glasdegib?
MediHelp rates the interaction as major. Chloramphenicol and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib is metabolized mainly by CYP3A4 and carries a risk of QT prolongation. Raising its exposure may increase QT effects and other dose-related toxicities.
How serious is the interaction between Chloramphenicol and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antibiotic if possible. If unavoidable, monitor ECG and electrolytes and watch for increased adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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