Drug interactions
Chloramphenicol + Gliclazide
Severity: Moderate
Chloramphenicol and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic drug metabolism and can increase sulfonylurea exposure, leading to prolonged or severe hypoglycemia. Gliclazide is metabolized by CYP2C9 and CYP2C19, which chloramphenicol can inhibit.
What this interaction means in plain words
Chloramphenicol and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Gliclazide belongs to Endocrine.
Why it happens
Inhibition of hepatic CYP-mediated metabolism of the sulfonylurea, increasing its plasma concentration.
What to do
Monitor blood glucose closely during chloramphenicol therapy and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Gliclazide?
MediHelp rates the interaction as moderate. Chloramphenicol and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic drug metabolism and can increase sulfonylurea exposure, leading to prolonged or severe hypoglycemia. Gliclazide is metabolized by CYP2C9 and CYP2C19, which chloramphenicol can inhibit.
How serious is the interaction between Chloramphenicol and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during chloramphenicol therapy and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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