Drug interactions
Chloramphenicol + Glipizide-metformin
Severity: Moderate
Chloramphenicol and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits hepatic drug metabolism and can raise sulfonylurea concentrations, increasing the risk of hypoglycemia. The effect is documented more clearly for older sulfonylureas, but may apply to glipizide.
What this interaction means in plain words
Chloramphenicol and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Glipizide-metformin belongs to Endocrine.
Why it happens
Inhibition of hepatic CYP-mediated metabolism of glipizide, reducing clearance.
What to do
Monitor blood glucose closely during chloramphenicol therapy and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Glipizide-metformin?
MediHelp rates the interaction as moderate. Chloramphenicol and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits hepatic drug metabolism and can raise sulfonylurea concentrations, increasing the risk of hypoglycemia. The effect is documented more clearly for older sulfonylureas, but may apply to glipizide.
How serious is the interaction between Chloramphenicol and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during chloramphenicol therapy and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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