Drug interactions
Chloramphenicol + Ivosidenib
Severity: Major
Chloramphenicol and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise ivosidenib concentrations. This could increase the risk of QT prolongation and differentiation syndrome.
What this interaction means in plain words
Chloramphenicol and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Ivosidenib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ivosidenib metabolism by chloramphenicol.
What to do
Prefer an alternative antibiotic. If coadministered, monitor ECG for QT prolongation and electrolytes and watch for differentiation syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Chloramphenicol with Ivosidenib?
MediHelp rates the interaction as major. Chloramphenicol and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may inhibit CYP3A4 and raise ivosidenib concentrations. This could increase the risk of QT prolongation and differentiation syndrome.
How serious is the interaction between Chloramphenicol and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If coadministered, monitor ECG for QT prolongation and electrolytes and watch for differentiation syndrome.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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