Drug interactions
Enzalutamide + Larotrectinib
Severity: Major
Enzalutamide and Larotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower larotrectinib concentrations and reduce its antitumor effect. Larotrectinib is a CYP3A4 substrate and is sensitive to strong induction.
What this interaction means in plain words
Enzalutamide and Larotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Larotrectinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing larotrectinib clearance.
What to do
Avoid if possible. If unavoidable, double the larotrectinib dose and return to the original dose after enzalutamide has been stopped for about 3 to 5 half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Enzalutamide with Larotrectinib?
MediHelp rates the interaction as major. Enzalutamide and Larotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may lower larotrectinib concentrations and reduce its antitumor effect. Larotrectinib is a CYP3A4 substrate and is sensitive to strong induction.
How serious is the interaction between Enzalutamide and Larotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, double the larotrectinib dose and return to the original dose after enzalutamide has been stopped for about 3 to 5 half-lives.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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