Drug interactions
Chloramphenicol + Lorlatinib
Severity: Major
Chloramphenicol and Lorlatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a CYP3A4 substrate and strong inhibitors markedly increase its exposure, raising the risk of hyperlipidemia, CNS effects and PR interval prolongation. Chloramphenicol is an inhibitor of uncertain potency.
What this interaction means in plain words
Chloramphenicol and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lorlatinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing lorlatinib metabolism.
What to do
Avoid the combination if possible. If needed, monitor ECG, lipids and mood or cognitive effects, and reduce the lorlatinib dose per labeling for CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Lorlatinib?
MediHelp rates the interaction as major. Chloramphenicol and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib is a CYP3A4 substrate and strong inhibitors markedly increase its exposure, raising the risk of hyperlipidemia, CNS effects and PR interval prolongation. Chloramphenicol is an inhibitor of uncertain potency.
How serious is the interaction between Chloramphenicol and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, monitor ECG, lipids and mood or cognitive effects, and reduce the lorlatinib dose per labeling for CYP3A inhibitors.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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