Drug interactions
Chloramphenicol + Lumateperone
Severity: Moderate
Chloramphenicol and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and may raise lumateperone plasma concentrations. Higher exposure can increase sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Chloramphenicol and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Lumateperone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lumateperone by chloramphenicol.
What to do
Monitor for excessive sedation and hypotension; labeling advises a reduced lumateperone dose with strong CYP3A4 inhibitors, so consider dose reduction if chloramphenicol is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Lumateperone
Frequently asked questions
Can I take Chloramphenicol with Lumateperone?
MediHelp rates the interaction as moderate. Chloramphenicol and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits CYP3A4 and may raise lumateperone plasma concentrations. Higher exposure can increase sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Chloramphenicol and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and hypotension; labeling advises a reduced lumateperone dose with strong CYP3A4 inhibitors, so consider dose reduction if chloramphenicol is needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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