Drug interactions
Chloramphenicol + Norgestrel
Severity: Minor
Chloramphenicol and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise norgestrel concentrations, potentially increasing progestogenic adverse effects. Contraceptive efficacy is not expected to fall.
What this interaction means in plain words
Chloramphenicol and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Norgestrel belongs to Endocrine.
Why it happens
CYP3A4 inhibition by chloramphenicol reduces norgestrel metabolism.
What to do
No routine change is needed; advise the patient to report breakthrough bleeding, headache or mood effects during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Chloramphenicol with Norgestrel?
MediHelp rates the interaction as minor. Chloramphenicol and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may raise norgestrel concentrations, potentially increasing progestogenic adverse effects. Contraceptive efficacy is not expected to fall.
How serious is the interaction between Chloramphenicol and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise the patient to report breakthrough bleeding, headache or mood effects during the antibiotic course.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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