Drug interactions
Chloramphenicol + Pimavanserin
Severity: Moderate
Chloramphenicol and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin is metabolized by CYP3A4 and prolongs the QT interval, so higher levels increase arrhythmia risk. Labeling recommends dose reduction with strong CYP3A4 inhibitors.
What this interaction means in plain words
Chloramphenicol and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, raising pimavanserin concentrations.
What to do
Monitor ECG and consider reducing the pimavanserin dose during chloramphenicol therapy. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Chloramphenicol with Pimavanserin?
MediHelp rates the interaction as moderate. Chloramphenicol and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin is metabolized by CYP3A4 and prolongs the QT interval, so higher levels increase arrhythmia risk. Labeling recommends dose reduction with strong CYP3A4 inhibitors.
How serious is the interaction between Chloramphenicol and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and consider reducing the pimavanserin dose during chloramphenicol therapy. Correct potassium and magnesium abnormalities.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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