Drug interactions
Chloramphenicol + Repaglinide
Severity: Moderate
Chloramphenicol and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise repaglinide exposure, leading to a risk of hypoglycemia. The effect is predicted from mechanism rather than well documented.
What this interaction means in plain words
Chloramphenicol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C8) metabolism of repaglinide.
What to do
Monitor blood glucose closely and teach the patient to recognize hypoglycemia. Reduce the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Chloramphenicol with Repaglinide?
MediHelp rates the interaction as moderate. Chloramphenicol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and raise repaglinide exposure, leading to a risk of hypoglycemia. The effect is predicted from mechanism rather than well documented.
How serious is the interaction between Chloramphenicol and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and teach the patient to recognize hypoglycemia. Reduce the repaglinide dose if glucose falls.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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