Drug interactions
Chloramphenicol + Selpercatinib
Severity: Moderate
Chloramphenicol and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase selpercatinib concentrations by inhibiting CYP3A4. Higher exposure may increase QT prolongation, hypertension and hepatotoxicity.
What this interaction means in plain words
Chloramphenicol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Selpercatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated selpercatinib metabolism by chloramphenicol.
What to do
Prefer an alternative antibiotic; if combined, monitor ECG, blood pressure and liver enzymes and consider reducing the selpercatinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Selpercatinib
Frequently asked questions
Can I take Chloramphenicol with Selpercatinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase selpercatinib concentrations by inhibiting CYP3A4. Higher exposure may increase QT prolongation, hypertension and hepatotoxicity.
How serious is the interaction between Chloramphenicol and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic; if combined, monitor ECG, blood pressure and liver enzymes and consider reducing the selpercatinib dose.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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