Drug interactions
Chloramphenicol + Tolterodine
Severity: Moderate
Chloramphenicol and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and may raise tolterodine exposure. This matters mainly in CYP2D6 poor metabolizers or those on other inhibitors, where anticholinergic effects and QT effects could increase.
What this interaction means in plain words
Chloramphenicol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 by chloramphenicol reduces tolterodine clearance.
What to do
Monitor for anticholinergic adverse effects such as dry mouth, constipation and urinary retention, and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Tolterodine?
MediHelp rates the interaction as moderate. Chloramphenicol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits CYP3A4 and may raise tolterodine exposure. This matters mainly in CYP2D6 poor metabolizers or those on other inhibitors, where anticholinergic effects and QT effects could increase.
How serious is the interaction between Chloramphenicol and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as dry mouth, constipation and urinary retention, and reduce the tolterodine dose if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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