Drug interactions
Chloramphenicol + Vinorelbine
Severity: Moderate
Chloramphenicol and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise vinorelbine exposure, which could worsen neutropenia and neuropathy. Both agents can also depress bone marrow function.
What this interaction means in plain words
Chloramphenicol and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vinorelbine belongs to Oncology.
Why it happens
CYP3A4 inhibition reducing vinorelbine clearance, with additive myelosuppression.
What to do
Monitor blood counts closely and watch for neuropathy and constipation. Consider an alternative antibiotic and reduce the vinorelbine dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Vinorelbine
Frequently asked questions
Can I take Chloramphenicol with Vinorelbine?
MediHelp rates the interaction as moderate. Chloramphenicol and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and raise vinorelbine exposure, which could worsen neutropenia and neuropathy. Both agents can also depress bone marrow function.
How serious is the interaction between Chloramphenicol and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for neuropathy and constipation. Consider an alternative antibiotic and reduce the vinorelbine dose if neutropenia develops.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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