Drug interactions
Chlordiazepoxide + Cinnarizine
Severity: Moderate
Chlordiazepoxide and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistaminic calcium channel blocker, and with a benzodiazepine it may increase drowsiness and reduce alertness. Motor impairment is a concern in older patients.
What this interaction means in plain words
Chlordiazepoxide and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 receptor blockade.
What to do
Counsel on drowsiness and avoiding driving and alcohol. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Cinnarizine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Chlordiazepoxide with Cinnarizine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistaminic calcium channel blocker, and with a benzodiazepine it may increase drowsiness and reduce alertness. Motor impairment is a concern in older patients.
How serious is the interaction between Chlordiazepoxide and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoiding driving and alcohol. Use the lowest effective doses.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
