Drug interactions
Amitriptyline + Cinnarizine
Severity: Moderate
Amitriptyline and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have antimuscarinic activity, so combined use may increase drowsiness and anticholinergic effects. Cinnarizine can also cause extrapyramidal symptoms, and impaired alertness raises the risk of accidents.
What this interaction means in plain words
Amitriptyline and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Cinnarizine belongs to Respiratory.
Why it happens
Additive H1-antagonist, CNS depressant and antimuscarinic effects.
What to do
Counsel about drowsiness and avoid driving until the response is known. Reduce doses or choose an alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
- Baclofen + Cinnarizine Moderate
Frequently asked questions
Can I take Amitriptyline with Cinnarizine?
MediHelp rates the interaction as moderate. Amitriptyline and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have antimuscarinic activity, so combined use may increase drowsiness and anticholinergic effects. Cinnarizine can also cause extrapyramidal symptoms, and impaired alertness raises the risk of accidents.
How serious is the interaction between Amitriptyline and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoid driving until the response is known. Reduce doses or choose an alternative in older patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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