Drug interactions
Azelastine + Cinnarizine
Severity: Moderate
Azelastine and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine, and azelastine may add to drowsiness. The combination may impair alertness and coordination.
What this interaction means in plain words
Azelastine and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-receptor antagonism.
What to do
Warn about additive drowsiness and advise against driving until the effect is known. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Baclofen + Cinnarizine Moderate
Frequently asked questions
Can I take Azelastine with Cinnarizine?
MediHelp rates the interaction as moderate. Azelastine and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine, and azelastine may add to drowsiness. The combination may impair alertness and coordination.
How serious is the interaction between Azelastine and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about additive drowsiness and advise against driving until the effect is known. Avoid alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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