Drug interactions
Chlordiazepoxide + Clobazam
Severity: Moderate
Chlordiazepoxide and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines used together increase sedation, cognitive impairment and the risk of respiratory depression without clear added benefit. Falls and accumulation are especially concerning in older or debilitated patients.
What this interaction means in plain words
Chlordiazepoxide and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid unnecessary therapeutic duplication; if both are required, use the lowest doses and monitor sedation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Chlordiazepoxide with Clobazam?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines used together increase sedation, cognitive impairment and the risk of respiratory depression without clear added benefit. Falls and accumulation are especially concerning in older or debilitated patients.
How serious is the interaction between Chlordiazepoxide and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary therapeutic duplication; if both are required, use the lowest doses and monitor sedation and respiration.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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