Drug interactions
Chlordiazepoxide + Clomipramine
Severity: Moderate
Chlordiazepoxide and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating tricyclic, and combined with a benzodiazepine it can increase drowsiness, cognitive impairment and orthostatic effects. Clomipramine also lowers the seizure threshold.
What this interaction means in plain words
Chlordiazepoxide and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and tricyclic antihistaminic, anticholinergic and alpha-blocking effects.
What to do
Monitor for sedation, confusion and orthostatic hypotension, and use the lowest effective doses. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Clomipramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating tricyclic, and combined with a benzodiazepine it can increase drowsiness, cognitive impairment and orthostatic effects. Clomipramine also lowers the seizure threshold.
How serious is the interaction between Chlordiazepoxide and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and orthostatic hypotension, and use the lowest effective doses. Advise against driving until the response is known.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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