Drug interactions
Chlordiazepoxide + Clorazepate
Severity: Major
Chlordiazepoxide and Clorazepate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together adds to sedation, psychomotor impairment and respiratory depression, with no meaningful therapeutic gain. Dependence risk and the chance of falls or accidents also increase.
What this interaction means in plain words
Chlordiazepoxide and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive enhancement of GABA-A receptor mediated inhibition by two benzodiazepines.
What to do
Avoid concurrent use and consolidate to a single benzodiazepine. If a temporary overlap is needed during a switch, use the lowest doses and monitor sedation and breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Clorazepate?
MediHelp rates the interaction as major. Chlordiazepoxide and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two benzodiazepines together adds to sedation, psychomotor impairment and respiratory depression, with no meaningful therapeutic gain. Dependence risk and the chance of falls or accidents also increase.
How serious is the interaction between Chlordiazepoxide and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and consolidate to a single benzodiazepine. If a temporary overlap is needed during a switch, use the lowest doses and monitor sedation and breathing.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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