Drug interactions
Chlordiazepoxide + Darunavir
Severity: Major
Chlordiazepoxide and Darunavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and can increase chlordiazepoxide exposure. Prolonged sedation and respiratory depression may result.
What this interaction means in plain words
Chlordiazepoxide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism by ritonavir or cobicistat-boosted darunavir.
What to do
Lower the chlordiazepoxide dose and monitor for oversedation, or switch to lorazepam or oxazepam.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Darunavir?
MediHelp rates the interaction as major. Chlordiazepoxide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Boosted darunavir inhibits CYP3A4 and can increase chlordiazepoxide exposure. Prolonged sedation and respiratory depression may result.
How serious is the interaction between Chlordiazepoxide and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the chlordiazepoxide dose and monitor for oversedation, or switch to lorazepam or oxazepam.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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