Drug interactions
Chlordiazepoxide + Dexchlorpheniramine
Severity: Moderate
Chlordiazepoxide and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating first-generation antihistamine. Taken with chlordiazepoxide it can add to drowsiness, slowed reaction time and cognitive impairment.
What this interaction means in plain words
Chlordiazepoxide and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and central H1 antagonism.
What to do
Warn patients about additive drowsiness and avoid driving or hazardous tasks. Consider a non-sedating antihistamine when appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Chlordiazepoxide with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating first-generation antihistamine. Taken with chlordiazepoxide it can add to drowsiness, slowed reaction time and cognitive impairment.
How serious is the interaction between Chlordiazepoxide and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive drowsiness and avoid driving or hazardous tasks. Consider a non-sedating antihistamine when appropriate.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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