Drug interactions
Chlordiazepoxide + Etomidate
Severity: Moderate
Chlordiazepoxide and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic that acts at GABA-A receptors, so prior benzodiazepine use can deepen sedation and lower anesthetic requirements. Respiratory depression and hypotension may be more pronounced.
What this interaction means in plain words
Chlordiazepoxide and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Etomidate belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Inform the anesthesia team of benzodiazepine use and titrate etomidate to effect with continuous monitoring of airway, oxygenation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Chlordiazepoxide with Etomidate?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic that acts at GABA-A receptors, so prior benzodiazepine use can deepen sedation and lower anesthetic requirements. Respiratory depression and hypotension may be more pronounced.
How serious is the interaction between Chlordiazepoxide and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of benzodiazepine use and titrate etomidate to effect with continuous monitoring of airway, oxygenation and blood pressure.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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