Drug interactions
Brompheniramine + Etomidate
Severity: Moderate
Brompheniramine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a hypnotic anesthetic induction agent, and a sedating antihistamine may add to its depressant effect. In practice the interaction is mainly relevant to anesthetic planning and recovery sedation.
What this interaction means in plain words
Brompheniramine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by etomidate and H1 antagonism by brompheniramine.
What to do
Inform the anesthesia team of recent antihistamine use. Titrate etomidate to effect and monitor recovery and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Buprenorphine + Etomidate Moderate
Frequently asked questions
Can I take Brompheniramine with Etomidate?
MediHelp rates the interaction as moderate. Brompheniramine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is a hypnotic anesthetic induction agent, and a sedating antihistamine may add to its depressant effect. In practice the interaction is mainly relevant to anesthetic planning and recovery sedation.
How serious is the interaction between Brompheniramine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent antihistamine use. Titrate etomidate to effect and monitor recovery and respiration.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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