Drug interactions
Amobarbital + Etomidate
Severity: Moderate
Amobarbital and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an anesthetic induction agent, and a barbiturate adds to its sedative and hypnotic effect. Greater CNS depression, hypotension and respiratory depression are possible.
What this interaction means in plain words
Amobarbital and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Etomidate belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Titrate the etomidate dose to effect and monitor airway, ventilation and blood pressure; anesthesia staff should be aware of recent barbiturate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amobarbital and Etomidate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
- Buprenorphine + Etomidate Moderate
Frequently asked questions
Can I take Amobarbital with Etomidate?
MediHelp rates the interaction as moderate. Amobarbital and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an anesthetic induction agent, and a barbiturate adds to its sedative and hypnotic effect. Greater CNS depression, hypotension and respiratory depression are possible.
How serious is the interaction between Amobarbital and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the etomidate dose to effect and monitor airway, ventilation and blood pressure; anesthesia staff should be aware of recent barbiturate use.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
