Drug interactions
Chlordiazepoxide + Etravirine
Severity: Moderate
Chlordiazepoxide and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower chlordiazepoxide concentrations, which could reduce its anxiolytic or withdrawal-suppressing effect. Etravirine also inhibits CYP2C19, which has little relevance to chlordiazepoxide.
What this interaction means in plain words
Chlordiazepoxide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, increasing metabolism of chlordiazepoxide.
What to do
Monitor for reduced clinical effect and increase the chlordiazepoxide dose if needed; recheck dosing when etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Chlordiazepoxide with Etravirine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower chlordiazepoxide concentrations, which could reduce its anxiolytic or withdrawal-suppressing effect. Etravirine also inhibits CYP2C19, which has little relevance to chlordiazepoxide.
How serious is the interaction between Chlordiazepoxide and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clinical effect and increase the chlordiazepoxide dose if needed; recheck dosing when etravirine is stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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