Drug interactions
Etravirine + Isavuconazole
Severity: Contraindicated
Etravirine and Isavuconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may reduce isavuconazole concentrations, risking antifungal failure. Isavuconazole may in turn raise etravirine exposure.
What this interaction means in plain words
Etravirine and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Etravirine belongs to Anti Virals; Isavuconazole belongs to Anti Fungals.
Why it happens
Etravirine induces CYP3A4/5 and increases isavuconazole clearance.
What to do
Avoid the combination and consider alternative antiretroviral or antifungal therapy. If unavoidable, monitor isavuconazole concentrations and clinical response.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
- Deflazacort + Etravirine Major
Frequently asked questions
Can I take Etravirine with Isavuconazole?
MediHelp rates the interaction as contraindicated. Etravirine and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Etravirine is a CYP3A4 inducer and may reduce isavuconazole concentrations, risking antifungal failure. Isavuconazole may in turn raise etravirine exposure.
How serious is the interaction between Etravirine and Isavuconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider alternative antiretroviral or antifungal therapy. If unavoidable, monitor isavuconazole concentrations and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Ketoconazole. The full list is on the Isavuconazole page.
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