Drug interactions
Efavirenz + Etravirine
Severity: Contraindicated
Efavirenz and Etravirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
What this interaction means in plain words
Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Etravirine belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4 and CYP2C19, increasing etravirine metabolism.
What to do
Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Etravirine
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
- Deflazacort + Etravirine Major
Frequently asked questions
Can I take Efavirenz with Etravirine?
MediHelp rates the interaction as contraindicated. Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
How serious is the interaction between Efavirenz and Etravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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