Drug interactions
Chlordiazepoxide + Fluphenazine
Severity: Moderate
Chlordiazepoxide and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a phenothiazine antipsychotic increases sedation and can lower blood pressure on standing. Psychomotor impairment and falls may increase, particularly in older patients.
What this interaction means in plain words
Chlordiazepoxide and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine, histamine and alpha-adrenergic blockade.
What to do
Start with low doses and titrate slowly. Monitor for oversedation and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Chlordiazepoxide with Fluphenazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with a phenothiazine antipsychotic increases sedation and can lower blood pressure on standing. Psychomotor impairment and falls may increase, particularly in older patients.
How serious is the interaction between Chlordiazepoxide and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly. Monitor for oversedation and orthostatic hypotension.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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