Drug interactions
Chlordiazepoxide + Haloperidol
Severity: Moderate
Chlordiazepoxide and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines are often combined with haloperidol for agitation, and together they increase sedation and may impair respiratory drive. Excessive sedation and confusion are more likely in older or medically ill patients.
What this interaction means in plain words
Chlordiazepoxide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement and dopamine D2 blockade.
What to do
Use the lowest effective doses and monitor sedation level and respiratory rate, especially with parenteral dosing. Reduce doses in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Haloperidol?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines are often combined with haloperidol for agitation, and together they increase sedation and may impair respiratory drive. Excessive sedation and confusion are more likely in older or medically ill patients.
How serious is the interaction between Chlordiazepoxide and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation level and respiratory rate, especially with parenteral dosing. Reduce doses in older patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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