Drug interactions
Chlordiazepoxide + Iloperidone
Severity: Moderate
Chlordiazepoxide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone causes sedation and orthostatic hypotension, which add to the CNS depression of chlordiazepoxide. Iloperidone may also modestly inhibit CYP3A4, potentially raising chlordiazepoxide exposure.
What this interaction means in plain words
Chlordiazepoxide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible CYP3A4 inhibition by iloperidone reducing chlordiazepoxide clearance.
What to do
Monitor for sedation, dizziness and hypotension, especially at initiation and after dose changes. Reduce the chlordiazepoxide dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chlordiazepoxide with Iloperidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone causes sedation and orthostatic hypotension, which add to the CNS depression of chlordiazepoxide. Iloperidone may also modestly inhibit CYP3A4, potentially raising chlordiazepoxide exposure.
How serious is the interaction between Chlordiazepoxide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and hypotension, especially at initiation and after dose changes. Reduce the chlordiazepoxide dose if excessive sedation occurs.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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