Drug interactions
Chlordiazepoxide + Letermovir
Severity: Moderate
Chlordiazepoxide and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and can increase exposure to CYP3A-metabolized drugs such as chlordiazepoxide. This may lead to deeper or longer sedation.
What this interaction means in plain words
Chlordiazepoxide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A-mediated metabolism of chlordiazepoxide by letermovir.
What to do
Monitor for oversedation and psychomotor impairment while on letermovir. Consider reducing the chlordiazepoxide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Chlordiazepoxide with Letermovir?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and can increase exposure to CYP3A-metabolized drugs such as chlordiazepoxide. This may lead to deeper or longer sedation.
How serious is the interaction between Chlordiazepoxide and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and psychomotor impairment while on letermovir. Consider reducing the chlordiazepoxide dose.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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