Drug interactions
Chlordiazepoxide + Nabilone
Severity: Moderate
Chlordiazepoxide and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlordiazepoxide is a long-acting benzodiazepine and nabilone also causes sedation and psychomotor impairment. The combination can produce excessive drowsiness, confusion, falls and, at higher doses, respiratory depression.
What this interaction means in plain words
Chlordiazepoxide and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Use the lowest effective doses and monitor sedation, especially in older adults. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Nabilone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlordiazepoxide is a long-acting benzodiazepine and nabilone also causes sedation and psychomotor impairment. The combination can produce excessive drowsiness, confusion, falls and, at higher doses, respiratory depression.
How serious is the interaction between Chlordiazepoxide and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, especially in older adults. Advise against driving and alcohol use.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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