Drug interactions
Chlordiazepoxide + Perphenazine
Severity: Moderate
Chlordiazepoxide and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation and psychomotor impairment, and phenothiazine-related hypotension can add to dizziness. Excess CNS depression may occur in older or debilitated patients.
What this interaction means in plain words
Chlordiazepoxide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and dopaminergic, histaminic and adrenergic blockade by perphenazine.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Counsel patients to avoid alcohol and hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Chlordiazepoxide with Perphenazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases sedation and psychomotor impairment, and phenothiazine-related hypotension can add to dizziness. Excess CNS depression may occur in older or debilitated patients.
How serious is the interaction between Chlordiazepoxide and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Counsel patients to avoid alcohol and hazardous tasks.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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