Drug interactions
Chlordiazepoxide + Tipranavir
Severity: Major
Chlordiazepoxide and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, is predominantly a CYP3A4 inhibitor and may increase chlordiazepoxide exposure, raising the risk of oversedation and respiratory depression.
What this interaction means in plain words
Chlordiazepoxide and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Net CYP3A4 inhibition by ritonavir-boosted tipranavir reduces chlordiazepoxide metabolism.
What to do
Use an alternative such as lorazepam or lower the chlordiazepoxide dose. Monitor for excess sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Tipranavir?
MediHelp rates the interaction as major. Chlordiazepoxide and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, is predominantly a CYP3A4 inhibitor and may increase chlordiazepoxide exposure, raising the risk of oversedation and respiratory depression.
How serious is the interaction between Chlordiazepoxide and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative such as lorazepam or lower the chlordiazepoxide dose. Monitor for excess sedation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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