Drug interactions
Chlordiazepoxide-clidinium + Cyclobenzaprine
Severity: Moderate
Chlordiazepoxide-clidinium and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a sedating, structurally tricyclic muscle relaxant, and combination with a benzodiazepine increases drowsiness and impaired coordination. Anticholinergic effects may add to those of clidinium.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic effects, especially in older adults, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a sedating, structurally tricyclic muscle relaxant, and combination with a benzodiazepine increases drowsiness and impaired coordination. Anticholinergic effects may add to those of clidinium.
How serious is the interaction between Chlordiazepoxide-clidinium and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, especially in older adults, and use the lowest effective doses.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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