Drug interactions
Chlordiazepoxide-clidinium + Diphenoxylate
Severity: Moderate
Chlordiazepoxide-clidinium and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid and can add to benzodiazepine CNS depression, causing sedation and possibly respiratory depression. Its atropine content and clidinium can add anticholinergic effects.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression via opioid agonism and GABA-A potentiation, plus additive anticholinergic effects.
What to do
Monitor sedation and respiratory status, and keep doses low and duration short. Watch for anticholinergic toxicity such as urinary retention and ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Diphenoxylate?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid and can add to benzodiazepine CNS depression, causing sedation and possibly respiratory depression. Its atropine content and clidinium can add anticholinergic effects.
How serious is the interaction between Chlordiazepoxide-clidinium and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and keep doses low and duration short. Watch for anticholinergic toxicity such as urinary retention and ileus.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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