Drug interactions
Chlordiazepoxide-clidinium + Dosulepin
Severity: Moderate
Chlordiazepoxide-clidinium and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant, and combining it with a benzodiazepine increases drowsiness and psychomotor impairment. Dosulepin is also anticholinergic and dangerous in overdose, so the combination adds to this burden.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Use the lowest effective doses and warn about driving and alcohol. Monitor older patients for sedation, confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Dosulepin?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant, and combining it with a benzodiazepine increases drowsiness and psychomotor impairment. Dosulepin is also anticholinergic and dangerous in overdose, so the combination adds to this burden.
How serious is the interaction between Chlordiazepoxide-clidinium and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about driving and alcohol. Monitor older patients for sedation, confusion and falls.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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