Drug interactions
Chlordiazepoxide-clidinium + Doxylamine
Severity: Moderate
Chlordiazepoxide-clidinium and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine with anticholinergic effects, and it adds to benzodiazepine sedation. Impaired alertness, confusion and falls are more likely, particularly in older adults.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Avoid combining for sleep in older adults and use the lowest doses otherwise. Counsel on next-day impairment and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Doxylamine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine with anticholinergic effects, and it adds to benzodiazepine sedation. Impaired alertness, confusion and falls are more likely, particularly in older adults.
How serious is the interaction between Chlordiazepoxide-clidinium and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining for sleep in older adults and use the lowest doses otherwise. Counsel on next-day impairment and avoid alcohol.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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