Drug interactions
Chlordiazepoxide-clidinium + Efavirenz
Severity: Moderate
Chlordiazepoxide-clidinium and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and may lower chlordiazepoxide exposure, possibly reducing its effect. Efavirenz itself causes dizziness and CNS effects, so additive CNS effects are also possible.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Efavirenz belongs to Anti Virals.
Why it happens
CYP3A4 induction by efavirenz increases chlordiazepoxide metabolism, plus overlapping CNS effects.
What to do
Monitor for reduced anxiolytic or withdrawal-suppressing effect and adjust the chlordiazepoxide dose to clinical response. Watch for additive dizziness and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Efavirenz?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and may lower chlordiazepoxide exposure, possibly reducing its effect. Efavirenz itself causes dizziness and CNS effects, so additive CNS effects are also possible.
How serious is the interaction between Chlordiazepoxide-clidinium and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic or withdrawal-suppressing effect and adjust the chlordiazepoxide dose to clinical response. Watch for additive dizziness and sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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